| 09/05/05 | hosting | Miami FL | 10-7 |
| 09/10/05 | hosting | The Citadel | 62-10 |
| 09/17/05 | at | Boston College | 28-17 |
| 10/01/05 | hosting | Syracuse | 38-14 |
| 10/08/05 | hosting | Wake Forest | 41-24 |
| 10/15/05 | at | Virginia | 21-26 |
| 10/22/05 | at | Duke | 55-24 |
| 10/29/05 | hosting | Maryland | 35-27 |
| 11/05/05 | hosting | North Carolina State | 15-20 |
| 11/12/05 | at | Clemson | 14-35 |
| 11/26/05 | at | Florida | 7-34 |
| 12/03/05 | vs. | Virginia Tech | 27-22 |
| 01/03/06 | vs. | Penn State | 23-26 3OT |