| 09/02/06 | at | Bowling Green | 35-14 |
| 09/09/06 | hosting | Western Illinois | 34-10 |
| 09/16/06 | hosting | San Diego St | 14-0 |
| 09/23/06 | at | Michigan | 13-27 |
| 09/30/06 | at | Indiana | 52-17 |
| 10/07/06 | hosting | Northwestern | 41-9 |
| 10/14/06 | hosting | Minnesota | 48-12 |
| 10/21/06 | at | Purdue | 24-3 |
| 10/28/06 | hosting | Illinois | 30-24 |
| 11/04/06 | hosting | Penn State | 13-3 |
| 11/11/06 | at | Iowa | 24-21 |
| 11/18/06 | hosting | Buffalo | 35-3 |
| 01/01/07 | at | Arkansas | 17-14 |