| 09/03/05 | hosting | Rutgers | 33-30 |
| 09/10/05 | hosting | San José St | 40-19 |
| 09/17/05 | at | California | 20-35 |
| 09/24/05 | hosting | Michigan State | 14-61 |
| 10/01/05 | at | Iowa | 7-35 |
| 10/08/05 | at | Indiana | 13-36 |
| 10/22/05 | hosting | Penn State | 10-63 |
| 10/29/05 | hosting | Wisconsin | 24-41 |
| 11/05/05 | at | Ohio State | 2-40 |
| 11/12/05 | at | Purdue | 3-37 |
| 11/19/05 | hosting | Northwestern | 21-38 |