| 09/03/05 | hosting | Washington U. | 33-7 |
| 09/17/05 | at | John Carroll | 70-0 |
| 09/24/05 | hosting | Otterbein | 55-7 |
| 10/01/05 | hosting | Capital | 42-24 |
| 10/08/05 | at | Wilmington | 41-6 |
| 10/15/05 | at | Marietta | 59-7 |
| 10/22/05 | hosting | Ohio Northern | 14-21 |
| 10/29/05 | hosting | Baldwin-Wallace | 17-3 |
| 11/05/05 | at | Muskingum | 45-0 |
| 11/12/05 | at | Heidelberg | 63-0 |
| 11/19/05 | hosting | Mt St Joseph | 49-6 |
| 11/26/05 | hosting | Augustana IL | 44-7 |
| 12/03/05 | hosting | Capital | 34-31 |
| 12/10/05 | hosting | Rowan | 19-7 |
| 12/17/05 | vs. | UW-Whitewater | 35-28 |