| 09/10/05 | hosting | Akron | 49-24 |
| 09/17/05 | at | Arizona | 31-24 |
| 09/24/05 | at | Minnesota | 35-42 2OT |
| 10/01/05 | hosting | Notre Dame | 28-49 |
| 10/08/05 | hosting | Iowa | 17-34 |
| 10/15/05 | hosting | Northwestern | 29-34 |
| 10/22/05 | at | Wisconsin | 20-31 |
| 10/29/05 | at | Penn State | 15-33 |
| 11/05/05 | hosting | Michigan State | 28-21 |
| 11/12/05 | hosting | Illinois | 37-3 |
| 11/19/05 | at | Indiana | 41-14 |