| 09/01/05 | hosting | Edward Waters | 60-7 |
| 09/10/05 | at | Baylor | 14-48 |
| 09/17/05 | at | Furman | 23-45 |
| 09/24/05 | at | Eastern Illinois | 14-43 |
| 09/29/05 | hosting | SE Missouri St | 33-17 |
| 10/08/05 | at | Eastern Kentucky | 6-38 |
| 10/15/05 | hosting | Murray State | 27-23 |
| 10/22/05 | at | Tennessee-Martin | 30-22 |
| 10/29/05 | hosting | Tennessee State | 31-11 |
| 11/05/05 | at | Tennessee Tech | 21-42 |
| 11/12/05 | hosting | Jacksonville State | 20-26 |