| 09/03/05 | at | Chattanooga | 23-30 |
| 09/08/05 | hosting | Lambuth | 52-10 |
| 09/17/05 | at | Northern Illinois | 3-42 |
| 09/24/05 | at | Eastern Kentucky | 3-52 |
| 10/01/05 | hosting | Murray State | 42-21 |
| 10/08/05 | at | Tennessee-Martin | 16-46 |
| 10/13/05 | hosting | Tennessee State | 20-31 |
| 10/29/05 | at | Jacksonville State | 17-43 |
| 11/05/05 | hosting | Samford | 42-21 |
| 11/12/05 | at | Eastern Illinois | 20-31 |
| 11/19/05 | hosting | SE Missouri St | 31-24 |