| 09/02/06 | at | Navy | 23-28 |
| 09/09/06 | at | Alabama-Birmingham | 12-17 |
| 09/16/06 | hosting | Memphis | 35-20 |
| 09/23/06 | hosting | West Virginia | 10-27 |
| 10/07/06 | hosting | Virginia | 31-21 |
| 10/14/06 | hosting | Tulsa | 10-31 |
| 10/21/06 | hosting | SMU | 38-21 |
| 10/28/06 | at | Southern Miss | 20-17 OT |
| 11/04/06 | at | Central Florida | 23-10 |
| 11/11/06 | hosting | Marshall | 33-20 |
| 11/18/06 | at | Rice | 17-18 |
| 11/25/06 | at | North Carolina St | 21-16 |
| 12/23/06 | at | South Florida | 7-24 |