| 09/02/06 | hosting | Montana | 41-7 |
| 09/09/06 | at | Syracuse | 20-13 2OT |
| 09/16/06 | hosting | Iowa St | 27-17 |
| 09/23/06 | at | Illinois | 24-7 |
| 09/30/06 | hosting | Ohio State | 17-38 |
| 10/07/06 | hosting | Purdue | 47-17 |
| 10/14/06 | at | Indiana | 28-31 |
| 10/21/06 | at | Michigan | 6-20 |
| 10/28/06 | hosting | Northern Illinois | 24-14 |
| 11/04/06 | hosting | Northwestern | 7-21 |
| 11/11/06 | hosting | Wisconsin | 21-24 |
| 11/18/06 | at | Minnesota | 24-34 |
| 12/30/06 | at | Texas | 24-26 |