| 11/19/05 | at | Jacksonville | 78-48 |
| 11/21/05 | hosting | Alcorn St. | 85-67 |
| 11/25/05 | at | Florida | 66-74 |
| 11/29/05 | hosting | Purdue | 97-57 |
| 12/02/05 | hosting | Louisiana Monroe | 85-62 |
| 12/07/05 | hosting | Texas Southern | 90-59 |
| 12/17/05 | vs. | Bowling Green | 71-60 |
| 12/20/05 | hosting | Stetson | 75-57 |
| 12/22/05 | hosting | Campbell | 108-73 |
| 12/31/05 | vs. | Nebraska | 74-60 |
| 01/04/06 | at | Clemson | 55-61 |
| 01/07/06 | hosting | Virginia Tech | 74-68 |
| 01/11/06 | at | Virginia | 87-82 OT |
| 01/14/06 | at | Boston College | 87-90 |
| 01/22/06 | hosting | North Carolina | 80-81 |
| 01/24/06 | at | Wake Forest | 75-68 |
| 01/29/06 | hosting | Miami FL | 78-84 OT |
| 02/01/06 | hosting | Clemson | 69-59 |
| 02/04/06 | at | Duke | 96-97 OT |
| 02/09/06 | hosting | Georgia Tech | 80-79 |
| 02/12/06 | hosting | Massachusetts | 73-63 |
| 02/15/06 | at | North Carolina St. | 64-86 |
| 02/18/06 | hosting | Virginia | 76-62 |
| 02/22/06 | hosting | Maryland | 71-60 |
| 02/25/06 | at | Virginia Tech | 61-72 |
| 03/01/06 | hosting | Duke | 79-74 |
| 03/05/06 | at | Miami FL | 67-64 |
| 03/09/06 | vs. | Wake Forest | 66-78 |
| 03/17/06 | hosting | Butler | 67-63 |
| 03/21/06 | hosting | South Carolina | 68-69 OT |