| 11/19/05 | at | Louisville | 61-78 |
| 11/26/05 | hosting | Webster | 94-72 |
| 12/01/05 | hosting | Arkansas St. | 80-77 OT |
| 12/03/05 | hosting | Southeast Missouri St. | 72-60 |
| 12/05/05 | hosting | Spalding | 79-59 |
| 12/10/05 | hosting | Jacksonville St. | 84-93 |
| 12/19/05 | at | Morehead St. | 80-67 |
| 12/21/05 | at | Eastern Kentucky | 61-75 |
| 12/28/05 | at | Purdue | 54-62 |
| 12/30/05 | at | Illinois | 46-84 |
| 01/02/06 | hosting | Austin Peay | 84-75 |
| 01/05/06 | hosting | Samford | 65-79 |
| 01/07/06 | at | Tennessee St. | 82-85 |
| 01/12/06 | at | Eastern Illinois | 70-80 OT |
| 01/14/06 | hosting | Morehead St. | 71-66 OT |
| 01/19/06 | at | Austin Peay | 88-96 |
| 01/21/06 | hosting | Murray St. | 73-79 |
| 01/26/06 | at | Samford | 60-67 |
| 01/28/06 | at | Jacksonville St. | 80-85 |
| 01/30/06 | hosting | Eastern Kentucky | 90-83 |
| 02/02/06 | hosting | Tennessee Tech | 88-78 |
| 02/04/06 | at | Southeast Missouri St. | 66-55 |
| 02/09/06 | hosting | Tennessee St. | 71-68 |
| 02/11/06 | hosting | Eastern Illinois | 85-61 |
| 02/16/06 | at | Tennessee Tech | 72-74 |
| 02/18/06 | at | Evansville | 69-62 |
| 02/25/06 | at | Murray St. | 63-81 |
| 02/28/06 | at | Murray St. | 52-65 |