| 11/15/05 | hosting | Southern | 89-56 |
| 11/16/05 | hosting | Samford | 77-33 |
| 11/21/05 | vs. | West Virginia | 76-75 |
| 11/22/05 | vs. | Iowa | 68-59 |
| 11/26/05 | hosting | Louisiana Monroe | 90-55 |
| 11/29/05 | hosting | Texas Pan American | 82-54 |
| 12/03/05 | hosting | Texas Arlington | 93-55 |
| 12/05/05 | at | Rice | 85-58 |
| 12/10/05 | vs. | Duke | 66-97 |
| 12/17/05 | hosting | Tennessee | 78-95 |
| 12/22/05 | hosting | Texas St. | 85-49 |
| 12/30/05 | hosting | Prairie View A&M | 110-38 |
| 01/02/06 | at | Memphis | 69-58 |
| 01/07/06 | hosting | Colorado | 89-64 |
| 01/09/06 | at | Iowa St. | 78-58 |
| 01/14/06 | hosting | Villanova | 58-55 |
| 01/17/06 | hosting | Texas Tech | 80-46 |
| 01/21/06 | at | Baylor | 66-47 |
| 01/23/06 | hosting | Oklahoma St. | 80-46 |
| 01/28/06 | at | Oklahoma | 72-82 |
| 02/01/06 | at | Missouri | 66-53 |
| 02/04/06 | hosting | Texas A&M | 83-70 |
| 02/06/06 | at | Texas Tech | 65-44 |
| 02/11/06 | hosting | Nebraska | 78-59 |
| 02/14/06 | hosting | Baylor | 90-63 |
| 02/19/06 | at | Oklahoma St. | 60-81 |
| 02/22/06 | at | Kansas St. | 65-64 |
| 02/25/06 | hosting | Kansas | 80-55 |
| 03/01/06 | at | Texas A&M | 43-46 |
| 03/05/06 | hosting | Oklahoma | 72-48 |
| 03/10/06 | vs. | Texas Tech | 77-70 |
| 03/11/06 | vs. | Texas A&M | 74-70 |
| 03/12/06 | vs. | Kansas | 68-80 |
| 03/17/06 | vs. | Pennsylvania | 60-52 |
| 03/19/06 | vs. | North Carolina St. | 75-54 |
| 03/23/06 | vs. | West Virginia | 74-71 |
| 03/25/06 | vs. | Louisiana St. | 60-70 OT |