| 11/18/05 | vs. | Norfolk St. | 80-51 |
| 11/19/05 | vs. | Eastern Kentucky | 95-89 2OT |
| 11/21/05 | vs. | Old Dominion | 84-81 |
| 11/26/05 | hosting | Coastal Carolina | 92-54 |
| 11/29/05 | at | Wake Forest | 88-91 |
| 12/03/05 | hosting | Pepperdine | 71-55 |
| 12/07/05 | hosting | Wisconsin Green Bay | 82-62 |
| 12/10/05 | hosting | Marquette | 77-63 |
| 12/12/05 | hosting | NC Wilmington | 54-51 |
| 12/15/05 | hosting | Wisconsin Milwaukee | 74-68 |
| 12/28/05 | hosting | Louisiana Tech | 78-52 |
| 12/31/05 | at | Pittsburgh | 64-73 |
| 01/05/06 | hosting | Iowa | 66-52 |
| 01/08/06 | hosting | Michigan St. | 82-63 |
| 01/10/06 | at | Minnesota | 64-62 |
| 01/14/06 | hosting | Northwestern | 68-52 |
| 01/18/06 | at | Ohio St. | 67-77 |
| 01/21/06 | hosting | North Dakota St. | 55-62 |
| 01/25/06 | hosting | Penn St. | 72-43 |
| 01/28/06 | at | Michigan | 76-85 |
| 01/31/06 | hosting | Illinois | 51-66 |
| 02/04/06 | at | Purdue | 62-70 |
| 02/08/06 | hosting | Indiana | 72-54 |
| 02/11/06 | at | Penn St. | 82-62 |
| 02/15/06 | hosting | Ohio St. | 78-73 |
| 02/23/06 | at | Northwestern | 51-62 |
| 02/26/06 | hosting | Minnesota | 80-74 |
| 03/02/06 | at | Michigan St. | 65-74 |
| 03/04/06 | at | Iowa | 44-59 |
| 03/10/06 | vs. | Indiana | 56-61 |
| 03/17/06 | vs. | Arizona | 75-94 |