| 10/14/05 | hosting | Quinnipiac | 4-3 OT |
| 10/16/05 | hosting | Maine | 5-3 |
| 10/18/05 | at | Boston University | 3-3 OT |
| 10/29/05 | vs. | Princeton | 2-2 OT |
| 10/30/05 | vs. | Niagara | 1-1 OT |
| 11/04/05 | at | New Hampshire | 0-4 |
| 11/05/05 | hosting | New Hampshire | 3-2 OT |
| 11/08/05 | hosting | Dartmouth | 2-3 |
| 11/12/05 | at | Yale | 1-1 OT |
| 11/19/05 | hosting | Connecticut | 2-1 |
| 11/22/05 | at | Quinnipiac | 3-4 |
| 12/03/05 | at | Connecticut | 6-1 |
| 12/04/05 | hosting | Providence | 2-4 |
| 12/10/05 | hosting | Northeastern | 5-4 |
| 12/30/05 | vs. | Clarkson | 0-1 |
| 12/31/05 | vs. | Clarkson | 1-2 OT |
| 01/02/06 | hosting | Yale | 2-3 |
| 01/09/06 | at | Northeastern | 2-1 |
| 01/12/06 | hosting | Vermont | 3-1 |
| 01/13/06 | hosting | Vermont | 3-0 |
| 01/16/06 | at | Vermont | 2-0 |
| 01/17/06 | hosting | Northeastern | 2-1 |
| 01/21/06 | hosting | Boston University | 5-2 |
| 01/22/06 | at | Boston University | 2-1 |
| 01/28/06 | hosting | Mercyhurst | 2-5 |
| 02/04/06 | hosting | New Hampshire | 1-6 |
| 02/07/06 | vs. | Northeastern | 4-3 OT |
| 02/11/06 | at | Connecticut | 4-0 |
| 02/14/06 | at | Harvard | 2-0 |
| 02/18/06 | at | Providence | 4-1 |
| 02/19/06 | hosting | Providence | 4-2 |
| 02/25/06 | at | Maine | 1-4 |
| 02/26/06 | at | Maine | 3-2 |
| 03/04/06 | vs. | Providence | 3-1 |
| 03/05/06 | vs. | New Hampshire | 0-6 |