| (63.24) | ||||
| 09/04/10 | hosting | Western Michigan | (57.79) | 38-14 |
| 09/11/10 | hosting | Florida Atlantic | (52.13) | 30-17 |
| 09/18/10 | hosting | Notre Dame | (64.98) | 34-31 OT |
| 09/25/10 | hosting | Northern Colorado | (52.23) | 45-7 |
| 10/02/10 | hosting | Wisconsin | (65.43) | 34-24 |
| 10/09/10 | at | Michigan | (59.24) | 34-17 |
| 10/16/10 | hosting | Illinois | (62.35) | 26-6 |
| 10/23/10 | at | Northwestern | (58.01) | 35-27 |
| 10/30/10 | at | Iowa | (62.98) | 6-37 |
| 11/06/10 | hosting | Minnesota | (57.56) | 31-8 |
| 11/20/10 | hosting | Purdue | (56.71) | 35-31 |
| 11/27/10 | at | Penn State | (59.93) | 28-22 |
| 01/01/11 | vs. | Alabama | (67.56) | 7-49 |