| 08/31/06 | at | San Diego St | 34-27 |
| 09/09/06 | hosting | Texas Tech | 35-38 OT |
| 09/23/06 | at | New Mexico | 13-26 |
| 09/30/06 | hosting | New Mexico St | 44-38 |
| 10/07/06 | hosting | SMU | 24-21 |
| 10/14/06 | hosting | Tulane | 34-20 |
| 10/21/06 | at | Houston | 17-34 |
| 10/27/06 | at | Tulsa | 20-30 |
| 11/04/06 | hosting | Rice | 31-37 |
| 11/10/06 | at | Alabama-Birmingham | 36-17 |
| 11/18/06 | at | Marshall | 21-49 |
| 11/25/06 | hosting | Memphis | 19-38 |