| 11/20/05 | hosting | Lafayette | 84-66 |
| 11/22/05 | hosting | Hofstra | 69-50 |
| 11/26/05 | vs. | North Carolina St. | 48-61 |
| 12/03/05 | hosting | Michigan | 67-71 |
| 12/07/05 | at | Alabama | 78-71 |
| 12/10/05 | hosting | Florida International | 81-47 |
| 12/18/05 | at | IUPU Fort Wayne | 65-63 |
| 12/21/05 | hosting | Niagara | 80-59 |
| 12/23/05 | hosting | Columbia | 75-68 |
| 12/28/05 | hosting | Fordham | 85-49 |
| 12/30/05 | hosting | Wofford | 74-71 |
| 01/04/06 | at | Pittsburgh | 97-100 2OT |
| 01/07/06 | at | DePaul | 67-73 |
| 01/11/06 | hosting | Syracuse | 82-88 |
| 01/14/06 | hosting | Providence | 92-77 |
| 01/20/06 | at | Marquette | 65-67 |
| 01/24/06 | hosting | Georgetown | 82-85 2OT |
| 01/28/06 | hosting | Villanova | 70-72 |
| 02/01/06 | at | West Virginia | 70-71 |
| 02/04/06 | at | Louisville | 86-89 OT |
| 02/08/06 | hosting | Rutgers | 90-63 |
| 02/15/06 | hosting | South Florida | 62-55 |
| 02/18/06 | at | Seton Hall | 102-91 |
| 02/21/06 | at | Connecticut | 74-75 OT |
| 02/25/06 | hosting | Marquette | 72-80 |
| 03/01/06 | at | Providence | 82-75 |
| 03/04/06 | hosting | DePaul | 66-61 |
| 03/08/06 | vs. | Georgetown | 63-67 |
| 03/15/06 | hosting | Vanderbilt | 79-69 |
| 03/20/06 | at | Michigan | 84-87 2OT |