| 11/19/05 | vs. | Old Dominion | 52-65 |
| 11/20/05 | vs. | Georgia | 68-79 |
| 11/21/05 | vs. | Norfolk St. | 72-53 |
| 11/26/05 | hosting | St. Francis NY | 60-66 |
| 11/28/05 | at | Siena | 54-64 |
| 12/01/05 | hosting | Iona | 70-71 |
| 12/04/05 | at | Holy Cross | 63-71 2OT |
| 12/07/05 | at | Virginia | 62-60 |
| 12/14/05 | at | Fairfield | 95-80 |
| 12/23/05 | at | Manhattan | 68-81 |
| 12/28/05 | at | Notre Dame | 49-85 |
| 12/31/05 | hosting | Lafayette | 71-52 |
| 01/04/06 | hosting | Dayton | 66-56 |
| 01/07/06 | at | Rhode Island | 59-64 |
| 01/09/06 | hosting | Pennsylvania | 78-63 |
| 01/15/06 | hosting | Duquesne | 90-63 |
| 01/18/06 | at | Massachusetts | 61-74 |
| 01/21/06 | hosting | St. Bonaventure | 79-72 2OT |
| 01/28/06 | at | St. Louis | 54-64 |
| 02/01/06 | hosting | Richmond | 63-45 |
| 02/04/06 | at | Duquesne | 90-81 |
| 02/09/06 | at | St. Bonaventure | 81-70 |
| 02/12/06 | hosting | Rhode Island | 79-76 2OT |
| 02/15/06 | at | Xavier | 64-84 |
| 02/18/06 | hosting | Charlotte | 75-81 |
| 02/22/06 | at | Saint Joseph's | 58-64 |
| 02/25/06 | hosting | George Washington | 67-78 |
| 03/01/06 | hosting | La Salle | 83-74 |
| 03/05/06 | at | Temple | 69-52 |
| 03/08/06 | vs. | Richmond | 45-37 |
| 03/09/06 | vs. | La Salle | 64-62 |
| 03/10/06 | at | Xavier | 59-70 |