| 11/19/05 | at | St. Francis PA | 58-71 |
| 11/23/05 | hosting | Slippery Rock | 95-53 |
| 11/26/05 | at | Akron | 62-67 |
| 11/30/05 | hosting | Kent St. | 69-77 |
| 12/04/05 | at | Marshall | 70-73 |
| 12/07/05 | at | Eastern Michigan | 71-77 |
| 12/10/05 | at | St. Bonaventure | 58-66 |
| 12/17/05 | hosting | Duquesne | 72-51 |
| 12/21/05 | hosting | James Madison | 72-65 |
| 12/28/05 | at | Siena | 67-75 |
| 12/31/05 | at | Illinois Chicago | 84-85 OT |
| 01/02/06 | at | Loyola Chicago | 84-76 |
| 01/05/06 | hosting | Wisconsin Green Bay | 95-70 |
| 01/07/06 | at | Detroit | 63-68 |
| 01/12/06 | hosting | Wright St. | 60-64 |
| 01/14/06 | hosting | Cleveland St. | 50-63 |
| 01/21/06 | hosting | Butler | 64-62 |
| 01/26/06 | hosting | Wisconsin Milwaukee | 70-78 |
| 01/28/06 | at | Cleveland St. | 68-63 |
| 01/30/06 | at | Wright St. | 67-81 |
| 02/02/06 | hosting | Illinois Chicago | 63-70 |
| 02/09/06 | at | Wisconsin Milwaukee | 57-98 |
| 02/11/06 | at | Wisconsin Green Bay | 58-80 |
| 02/15/06 | hosting | Detroit | 54-65 |
| 02/18/06 | at | Canisius | 68-75 |
| 02/22/06 | at | Butler | 64-72 |
| 02/25/06 | hosting | Loyola Chicago | 84-87 OT |
| 02/28/06 | at | Loyola Chicago | 61-76 |