| 11/18/05 | hosting | Robert Morris | 80-61 |
| 11/21/05 | at | Niagara | 88-101 |
| 11/26/05 | hosting | Canisius | 77-55 |
| 11/30/05 | vs. | West Virginia | 61-66 |
| 12/03/05 | hosting | St. Francis PA | 69-65 |
| 12/05/05 | hosting | Central Connecticut | 85-56 |
| 12/10/05 | hosting | Youngstown St. | 66-58 |
| 12/17/05 | at | Toledo | 68-83 |
| 12/21/05 | at | Marist | 51-69 |
| 12/27/05 | at | Florida International | 69-65 OT |
| 12/28/05 | vs. | Texas San Antonio | 55-76 |
| 01/03/06 | at | St. Louis | 58-60 |
| 01/07/06 | at | Xavier | 71-99 |
| 01/11/06 | hosting | Temple | 66-83 |
| 01/14/06 | hosting | Rhode Island | 66-71 |
| 01/21/06 | at | Fordham | 72-79 2OT |
| 01/25/06 | at | Dayton | 58-78 |
| 01/28/06 | hosting | Duquesne | 82-86 |
| 02/01/06 | hosting | Charlotte | 60-76 |
| 02/04/06 | at | Saint Joseph's | 51-82 |
| 02/09/06 | hosting | Fordham | 70-81 |
| 02/12/06 | hosting | Richmond | 71-57 |
| 02/15/06 | at | La Salle | 62-74 |
| 02/19/06 | hosting | Massachusetts | 64-72 |
| 02/25/06 | at | Duquesne | 77-76 |
| 03/01/06 | hosting | George Washington | 78-89 |
| 03/04/06 | at | Richmond | 64-65 |