| (52.17) | ||||
| 09/13/10 | hosting | Baltimore | (52.09) | 9-10 |
| 09/19/10 | hosting | New England | (53.09) | 28-14 |
| 09/26/10 | at | Miami | (50.16) | 31-23 |
| 10/03/10 | at | Buffalo | (49.47) | 38-14 |
| 10/11/10 | hosting | Minnesota | (49.85) | 29-20 |
| 10/17/10 | at | Denver | (47.62) | 24-20 |
| 10/31/10 | hosting | Green Bay | (53.03) | 0-9 |
| 11/07/10 | at | Detroit | (50.30) | 23-20 OT |
| 11/14/10 | at | Cleveland | (49.72) | 26-20 OT |
| 11/21/10 | hosting | Houston | (49.03) | 30-27 |
| 11/25/10 | hosting | Cincinnati | (49.08) | 26-10 |
| 12/06/10 | at | New England | (53.09) | 3-45 |
| 12/12/10 | hosting | Miami | (50.16) | 6-10 |
| 12/19/10 | at | Pittsburgh | (52.04) | 22-17 |
| 12/26/10 | at | Chicago | (51.15) | 34-38 |
| 01/02/11 | hosting | Buffalo | (49.47) | 38-7 |
| 01/08/11 | at | Indianapolis | (50.01) | 17-16 |
| 01/16/11 | at | New England | (53.09) | 28-21 |
| 01/23/11 | at | Pittsburgh | (52.04) | 19-24 |