| 09/10/05 | hosting | Kalamazoo | 46-6 |
| 09/17/05 | at | Washington U. | 23-7 |
| 09/24/05 | hosting | Earlham | 50-2 |
| 10/01/05 | at | Ohio Wesleyan | 29-7 |
| 10/08/05 | hosting | Oberlin | 42-7 |
| 10/15/05 | at | Wooster | 44-10 |
| 10/22/05 | hosting | Wittenberg | 26-20 |
| 10/29/05 | at | Allegheny | 27-21 |
| 11/05/05 | hosting | Denison | 52-0 |
| 11/12/05 | at | DePauw | 17-14 |
| 11/19/05 | hosting | Albion | 38-20 |
| 11/26/05 | hosting | Capital | 11-14 |