| 08/25/05 | at | Tusculum | 0-21 |
| 09/03/05 | at | Liberty | 6-17 |
| 09/10/05 | at | Fairmont St | 7-34 |
| 09/17/05 | at | West Liberty St | 24-23 |
| 09/24/05 | hosting | WV Wesleyan | 14-23 |
| 10/01/05 | at | Charleston WV | 7-30 |
| 10/08/05 | hosting | West Virginia St | 24-13 |
| 10/15/05 | hosting | Shepherd | 21-48 |
| 10/22/05 | at | Glenville St | 15-59 |
| 10/29/05 | hosting | West Virginia Tech | 51-6 |
| 11/05/05 | hosting | North Greenville | 37-34 |