| 09/02/06 | at | Purdue | 35-60 |
| 09/09/06 | at | Eastern Illinois | 21-31 |
| 09/16/06 | hosting | Murray St | 40-59 |
| 09/23/06 | at | Northern Illinois | 14-48 |
| 09/30/06 | at | Southern Illinois | 3-55 |
| 10/07/06 | at | Youngstown St | 17-55 |
| 10/14/06 | hosting | Northern Iowa | 14-34 |
| 10/21/06 | hosting | Missouri St | 28-22 |
| 10/28/06 | at | Western Kentucky | 3-41 |
| 11/04/06 | at | Western Illinois | 41-46 |
| 11/11/06 | hosting | Illinois St | 20-42 |