| 09/03/05 | at | Benedictine IL | 52-6 |
| 09/10/05 | hosting | Concordia IL | 55-14 |
| 09/17/05 | at | Chicago | 21-17 |
| 10/01/05 | hosting | Illinois Wesleyan | 20-15 |
| 10/08/05 | at | North Park | 28-12 |
| 10/15/05 | hosting | Wheaton | 7-24 |
| 10/22/05 | hosting | North Central | 21-28 |
| 10/29/05 | at | Augustana IL | 42-64 |
| 11/05/05 | at | Millikin | 45-35 |
| 11/12/05 | hosting | Carthage | 20-41 |