| 09/10/05 | hosting | Centre | 25-36 |
| 09/17/05 | hosting | Case Western Reserve | 8-19 |
| 09/24/05 | at | Kalamazoo | 26-38 |
| 10/01/05 | at | Oberlin | 21-20 |
| 10/08/05 | at | Wooster | 24-21 |
| 10/15/05 | hosting | Allegheny | 34-27 |
| 10/22/05 | hosting | Ohio Wesleyan | 14-41 |
| 10/29/05 | at | Earlham | 16-13 |
| 11/05/05 | at | Hiram | 41-38 |
| 11/12/05 | hosting | Denison | 45-42 |