| 09/03/05 | at | WV Wesleyan | 33-41 |
| 09/10/05 | hosting | California PA | 12-88 |
| 09/17/05 | at | Clarion | 12-15 |
| 09/24/05 | hosting | Kutztown | 18-45 |
| 10/01/05 | at | Lock Haven | 12-24 |
| 10/08/05 | hosting | Cheyney | 38-17 |
| 10/15/05 | at | West Chester | 20-63 |
| 10/22/05 | hosting | Bloomsburg | 12-40 |
| 10/29/05 | at | Millersville | 14-31 |
| 11/05/05 | at | East Stroudsburg | 20-57 |
| 11/12/05 | at | Coastal Carolina | 8-71 |