| 09/03/05 | at | Tennessee State | 27-14 |
| 09/10/05 | at | Grambling State | 0-44 |
| 09/17/05 | hosting | Mississippi Valley St | 27-13 |
| 09/24/05 | hosting | Allen | 42-0 |
| 10/01/05 | hosting | Texas Southern | 7-17 |
| 10/08/05 | at | Southern U. | 20-7 |
| 10/22/05 | hosting | Arkansas-Pine Bluff | 28-13 |
| 10/29/05 | vs. | Alabama St | 31-28 |
| 11/05/05 | hosting | Jackson State | 52-6 |
| 11/12/05 | at | Alcorn St | 28-21 |
| 11/19/05 | at | Prairie View A&M | 31-16 |
| 12/10/05 | vs. | Grambling State | 6-45 |