| 09/02/05 | hosting | Worcester St | 23-18 |
| 09/10/05 | at | Fitchburg St | 13-28 |
| 09/17/05 | at | Maine Maritime | 21-28 |
| 09/24/05 | hosting | UMass-Dartmouth | 34-6 |
| 10/01/05 | hosting | MIT | 50-13 |
| 10/08/05 | at | Salve Regina | 28-0 |
| 10/16/05 | at | Nichols | 41-7 |
| 10/22/05 | hosting | Endicott | 21-16 |
| 10/29/05 | hosting | Western New England | 42-27 |
| 11/05/05 | at | Westfield St | 31-21 |
| 11/12/05 | hosting | Fitchburg St | 17-14 |
| 11/19/05 | at | Delaware Valley | 22-37 |