| 08/27/05 | hosting | West Liberty St | 24-20 |
| 09/10/05 | hosting | Bethel TN | 20-14 |
| 09/17/05 | hosting | St Francis IL | 31-3 |
| 09/24/05 | at | St Xavier | 20-35 |
| 10/01/05 | at | St Francis IN | 22-50 |
| 10/08/05 | hosting | Malone | 14-15 |
| 10/15/05 | hosting | Quincy | 52-21 |
| 10/22/05 | at | Walsh | 21-20 |
| 10/29/05 | at | Taylor | 42-0 |
| 11/05/05 | hosting | Ohio Dominican | 29-28 |
| 11/12/05 | hosting | Urbana | 21-20 |
| 11/19/05 | at | Georgetown KY | 35-36 |