| 09/03/05 | at | Wofford | 24-34 |
| 09/17/05 | hosting | Belhaven | 41-15 |
| 09/24/05 | at | Bacone | 17-24 |
| 10/01/05 | hosting | Bethel TN | 30-29 |
| 10/08/05 | at | Campbellsville | 45-0 |
| 10/15/05 | at | Virginia-Wise | 51-6 |
| 10/22/05 | hosting | Union KY | 42-24 |
| 10/29/05 | hosting | Pikeville | 21-19 |
| 11/05/05 | at | Shorter | 79-6 |
| 11/12/05 | at | Cumberlands KY | 65-27 |
| 11/19/05 | hosting | Geneva | 36-35 |
| 11/26/05 | at | St Francis IN | 14-44 |