| 09/03/05 | at | North Park | 13-23 |
| 09/10/05 | hosting | Bacone | 24-27 |
| 09/24/05 | hosting | Cumberlands KY | 7-44 |
| 10/01/05 | at | Pikeville | 33-47 |
| 10/08/05 | at | Virginia-Wise | 15-7 |
| 10/15/05 | hosting | Campbellsville | 34-30 |
| 10/22/05 | hosting | Bethel TN | 0-47 |
| 10/29/05 | at | Cumberland TN | 32-22 |
| 11/05/05 | at | Belhaven | 35-45 |
| 11/12/05 | hosting | Lambuth | 23-27 |