| 09/07/06 | hosting | Central Oklahoma | 24-18 |
| 09/16/06 | at | SE Oklahoma St | 51-14 |
| 09/23/06 | hosting | SW Oklahoma St | 31-0 |
| 09/30/06 | at | Eastern New Mexico | 21-0 |
| 10/07/06 | at | Northeastern St OK | 45-20 |
| 10/14/06 | hosting | Angelo St | 35-7 |
| 10/19/06 | at | West Texas A&M | 49-33 |
| 10/28/06 | hosting | Tarleton St | 36-37 |
| 11/04/06 | at | TAMU-Kingsville | 41-38 |
| 11/11/06 | hosting | Midwestern St | 30-46 |
| 11/18/06 | at | West Texas A&M | 27-30 |