| 09/07/06 | at | Northeastern St OK | 7-42 |
| 09/16/06 | at | East Central OK | 24-15 |
| 09/23/06 | hosting | Central Oklahoma | 16-19 |
| 09/30/06 | hosting | Abilene Christian | 0-21 |
| 10/07/06 | at | Angelo St | 7-17 |
| 10/14/06 | hosting | West Texas A&M | 14-21 |
| 10/21/06 | at | Tarleton St | 0-48 |
| 10/28/06 | hosting | TAMU-Kingsville | 37-14 |
| 11/04/06 | at | Midwestern St | 19-29 |
| 11/11/06 | hosting | OK Panhandle St | 63-14 |