| 08/27/05 | at | West Virginia St | 40-7 |
| 09/03/05 | hosting | Johnson C. Smith | 12-9 |
| 09/10/05 | at | Morgan State | 35-21 |
| 09/17/05 | hosting | Livingstone | 33-15 |
| 09/24/05 | at | North Carolina Central | 19-38 |
| 10/01/05 | hosting | Shaw | 20-22 |
| 10/08/05 | at | Elizabeth City St | 13-8 |
| 10/15/05 | hosting | St Paul's | 21-7 |
| 10/22/05 | at | Virginia Union | 42-14 |
| 10/29/05 | at | Virginia St | 27-17 |
| 11/05/05 | at | North Carolina Central | 23-26 |
| 12/03/05 | vs. | Tuskegee | 26-28 |