| 08/27/05 | hosting | Edward Waters | 70-12 |
| 09/05/05 | vs. | North Carolina A&T | 23-22 |
| 09/10/05 | at | Lenoir-Rhyne | 28-21 |
| 09/17/05 | hosting | Shaw | 37-31 |
| 09/24/05 | hosting | Bowie St | 38-19 |
| 10/01/05 | hosting | St Augustine's | 8-22 |
| 10/08/05 | hosting | Fayetteville St | 17-12 |
| 10/15/05 | at | Winston-Salem St | 20-17 |
| 10/22/05 | hosting | Livingstone | 48-14 |
| 10/29/05 | at | Johnson C. Smith | 34-14 |
| 11/05/05 | hosting | Bowie St | 26-23 |
| 11/19/05 | hosting | North Alabama | 21-24 |