| 09/02/06 | hosting | Wisconsin | 14-35 |
| 09/09/06 | hosting | Buffalo | 48-40 OT |
| 09/16/06 | at | Florida Int'l | 33-28 |
| 09/23/06 | hosting | Kent St | 3-38 |
| 09/30/06 | at | Ohio U. | 21-9 |
| 10/07/06 | at | Ohio State | 7-35 |
| 10/14/06 | hosting | Eastern Michigan | 24-21 |
| 10/19/06 | at | Central Michigan | 14-31 |
| 10/28/06 | at | Temple | 14-28 |
| 11/04/06 | at | Akron | 28-35 |
| 11/15/06 | hosting | Miami OH | 7-9 |
| 11/21/06 | at | Toledo | 21-31 |