| 08/31/06 | hosting | Minnesota | 0-44 |
| 09/09/06 | at | Army | 14-17 OT |
| 09/16/06 | at | Miami OH | 16-14 |
| 09/23/06 | at | Bowling Green | 38-3 |
| 09/30/06 | hosting | Akron | 37-15 |
| 10/07/06 | at | Temple | 28-17 |
| 10/14/06 | hosting | Toledo | 40-14 |
| 10/28/06 | hosting | Ohio U. | 7-17 |
| 11/04/06 | at | Buffalo | 14-41 |
| 11/11/06 | at | Virginia Tech | 0-23 |
| 11/17/06 | hosting | Eastern Michigan | 14-6 |
| 11/24/06 | at | Ball St | 6-30 |