| 09/01/05 | hosting | Furman | 35-37 |
| 09/10/05 | hosting | Chattanooga | 18-21 |
| 09/17/05 | at | Alabama-Birmingham | 28-35 |
| 09/24/05 | at | SE Missouri St | 24-10 |
| 10/01/05 | hosting | Eastern Kentucky | 14-31 |
| 10/08/05 | at | Murray State | 28-23 |
| 10/15/05 | hosting | Tennessee-Martin | 37-17 |
| 10/22/05 | at | Tennessee State | 33-3 |
| 10/29/05 | hosting | Tennessee Tech | 43-17 |
| 11/12/05 | at | Samford | 26-20 |
| 11/19/05 | hosting | Eastern Illinois | 6-10 |