| 09/01/05 | hosting | Southern Illinois | 23-58 |
| 09/10/05 | at | Kent St | 12-33 |
| 09/17/05 | at | Missouri St | 21-45 |
| 09/24/05 | hosting | Jacksonville State | 10-24 |
| 09/29/05 | at | Samford | 17-33 |
| 10/08/05 | hosting | Eastern Illinois | 24-48 |
| 10/22/05 | at | Eastern Kentucky | 32-33 |
| 10/29/05 | hosting | Murray State | 52-21 |
| 11/05/05 | at | Tennessee-Martin | 21-24 |
| 11/12/05 | hosting | Tennessee State | 32-24 |
| 11/19/05 | at | Tennessee Tech | 24-31 |